Drug interactions
Amlodipine-benazepril + Bupivacaine
Severity: Moderate
Amlodipine-benazepril and Bupivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neuraxial or regional bupivacaine causes sympathetic blockade and hypotension, which may be intensified in patients taking antihypertensives such as benazepril and amlodipine. ACE inhibitors in particular are associated with refractory hypotension under anesthesia.
What this interaction means in plain words
Amlodipine-benazepril and Bupivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Bupivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from sympathetic blockade and RAAS inhibition and vasodilation.
What to do
Inform the anesthesia team about the antihypertensives and monitor blood pressure closely during blocks. Consider holding the ACE inhibitor before major surgery per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
- Bupivacaine + Iloprost Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Bupivacaine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bupivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neuraxial or regional bupivacaine causes sympathetic blockade and hypotension, which may be intensified in patients taking antihypertensives such as benazepril and amlodipine. ACE inhibitors in particular are associated with refractory hypotension under anesthesia.
How serious is the interaction between Amlodipine-benazepril and Bupivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about the antihypertensives and monitor blood pressure closely during blocks. Consider holding the ACE inhibitor before major surgery per local protocol.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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