Drug interactions
Buprenorphine + Carbinoxamine
Severity: Moderate
Buprenorphine and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine, and combined with buprenorphine it increases drowsiness, impaired psychomotor performance and, less commonly, respiratory depression. Anticholinergic effects such as constipation and urinary retention may also be additive.
What this interaction means in plain words
Buprenorphine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Carbinoxamine belongs to Respiratory.
Why it happens
Additive CNS depression from opioid agonism and central H1-receptor antagonism.
What to do
Use the lowest effective doses and counsel patients about drowsiness and avoiding driving. Monitor elderly patients more closely for sedation and respiratory effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Buprenorphine with Carbinoxamine?
MediHelp rates the interaction as moderate. Buprenorphine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine, and combined with buprenorphine it increases drowsiness, impaired psychomotor performance and, less commonly, respiratory depression. Anticholinergic effects such as constipation and urinary retention may also be additive.
How serious is the interaction between Buprenorphine and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about drowsiness and avoiding driving. Monitor elderly patients more closely for sedation and respiratory effects.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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