Drug interactions
Amitriptyline + Carbinoxamine
Severity: Moderate
Amitriptyline and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating antihistamine with anticholinergic properties, and amitriptyline has the same type of effects. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
What this interaction means in plain words
Amitriptyline and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Carbinoxamine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for sedation and anticholinergic effects, and avoid in older patients where possible. Consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
- Azelastine + Carbinoxamine Moderate
Frequently asked questions
Can I take Amitriptyline with Carbinoxamine?
MediHelp rates the interaction as moderate. Amitriptyline and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating antihistamine with anticholinergic properties, and amitriptyline has the same type of effects. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
How serious is the interaction between Amitriptyline and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, and avoid in older patients where possible. Consider a non-sedating antihistamine as an alternative.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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