Drug interactions
Azelastine-fluticasone + Carbinoxamine
Severity: Moderate
Azelastine-fluticasone and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a first-generation sedating antihistamine and duplicates the H1-blocking and sedating effects of azelastine. Combined use may increase drowsiness and anticholinergic effects.
What this interaction means in plain words
Azelastine-fluticasone and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Carbinoxamine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism and CNS depression.
What to do
Avoid using two antihistamines concurrently when possible. If both are needed, monitor for sedation and counsel about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine + Carbinoxamine Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Carbinoxamine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a first-generation sedating antihistamine and duplicates the H1-blocking and sedating effects of azelastine. Combined use may increase drowsiness and anticholinergic effects.
How serious is the interaction between Azelastine-fluticasone and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antihistamines concurrently when possible. If both are needed, monitor for sedation and counsel about driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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