Drug interactions
Buprenorphine + Cariprazine
Severity: Moderate
Buprenorphine and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and together they may produce additive drowsiness and psychomotor impairment. Serious respiratory depression is uncommon.
What this interaction means in plain words
Buprenorphine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation after starting or titrating either drug. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Buprenorphine with Cariprazine?
MediHelp rates the interaction as moderate. Buprenorphine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and together they may produce additive drowsiness and psychomotor impairment. Serious respiratory depression is uncommon.
How serious is the interaction between Buprenorphine and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation after starting or titrating either drug. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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