Drug interactions
Buprenorphine + Chlorzoxazone
Severity: Moderate
Buprenorphine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that can add to buprenorphine-induced sedation and dizziness. Concurrent use raises the risk of impaired alertness and, at higher doses, respiratory depression.
What this interaction means in plain words
Buprenorphine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective dose of each drug and monitor for sedation and respiratory depression, especially at initiation or after dose increases. Advise the patient not to drive or operate machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Buprenorphine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Buprenorphine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that can add to buprenorphine-induced sedation and dizziness. Concurrent use raises the risk of impaired alertness and, at higher doses, respiratory depression.
How serious is the interaction between Buprenorphine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and monitor for sedation and respiratory depression, especially at initiation or after dose increases. Advise the patient not to drive or operate machinery until the response is known.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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