Drug interactions
Buprenorphine + Deutetrabenazine
Severity: Moderate
Buprenorphine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and each has some potential for QT prolongation, so the combination may add to drowsiness and arrhythmia risk. Deutetrabenazine does not prolong the QT interval meaningfully at recommended doses, so the QT risk is mainly relevant with other risk factors.
What this interaction means in plain words
Buprenorphine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive QT prolongation.
What to do
Monitor sedation and consider an ECG if the patient has bradycardia, electrolyte disturbance, congenital QT prolongation or takes other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Buprenorphine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Buprenorphine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and each has some potential for QT prolongation, so the combination may add to drowsiness and arrhythmia risk. Deutetrabenazine does not prolong the QT interval meaningfully at recommended doses, so the QT risk is mainly relevant with other risk factors.
How serious is the interaction between Buprenorphine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider an ECG if the patient has bradycardia, electrolyte disturbance, congenital QT prolongation or takes other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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