Drug interactions
Deutetrabenazine + Selegiline
Severity: Contraindicated
Deutetrabenazine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
What this interaction means in plain words
Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Deutetrabenazine depletes and releases monoamines while MAO inhibition blocks their breakdown, so catecholamines can accumulate and cause a pressor response.
What to do
Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Selegiline?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
How serious is the interaction between Deutetrabenazine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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