Drug interactions
Deutetrabenazine + Safinamide
Severity: Contraindicated
Deutetrabenazine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
What this interaction means in plain words
Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Vesicular monoamine depletion by deutetrabenazine together with MAO inhibition causes unstable catecholamine effects.
What to do
Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
- Deutetrabenazine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Safinamide?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
How serious is the interaction between Deutetrabenazine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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