Drug interactions
Buprenorphine + Fostemsavir
Severity: Moderate
Buprenorphine and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active form (temsavir) prolongs the QT interval at supratherapeutic exposures, and buprenorphine has modest QT effects. The combination may add arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Buprenorphine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Fostemsavir belongs to Anti Virals.
Why it happens
Additive QTc prolongation.
What to do
Monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Buprenorphine with Fostemsavir?
MediHelp rates the interaction as moderate. Buprenorphine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active form (temsavir) prolongs the QT interval at supratherapeutic exposures, and buprenorphine has modest QT effects. The combination may add arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Buprenorphine and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Correct potassium and magnesium before starting.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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