Drug interactions
Fostemsavir + Mitotane
Severity: Contraindicated
Fostemsavir and Mitotane: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong, long-acting CYP3A4 inducer and is expected to lower temsavir concentrations. Induction persists for weeks after stopping mitotane.
What this interaction means in plain words
Fostemsavir and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fostemsavir belongs to Anti Virals; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing temsavir metabolism.
What to do
Avoid the combination, including shortly after mitotane discontinuation; choose an alternative antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
- Aripiprazole + Mitotane Major
Frequently asked questions
Can I take Fostemsavir with Mitotane?
MediHelp rates the interaction as contraindicated. Fostemsavir and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mitotane is a strong, long-acting CYP3A4 inducer and is expected to lower temsavir concentrations. Induction persists for weeks after stopping mitotane.
How serious is the interaction between Fostemsavir and Mitotane?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, including shortly after mitotane discontinuation; choose an alternative antiretroviral.
What other medicines interact with Fostemsavir?
MediHelp also lists interactions of Fostemsavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Fostemsavir page.
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