Drug interactions
Enzalutamide + Fostemsavir
Severity: Contraindicated
Enzalutamide and Fostemsavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active moiety temsavir is a CYP3A4 substrate, and strong inducers substantially lower its concentrations. Labeling contraindicates the combination because of loss of virologic response and resistance.
What this interaction means in plain words
Enzalutamide and Fostemsavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Fostemsavir belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4, increasing temsavir clearance.
What to do
Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if inducer exposure was recent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Enzalutamide + Lonafarnib Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
Frequently asked questions
Can I take Enzalutamide with Fostemsavir?
MediHelp rates the interaction as contraindicated. Enzalutamide and Fostemsavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fostemsavir's active moiety temsavir is a CYP3A4 substrate, and strong inducers substantially lower its concentrations. Labeling contraindicates the combination because of loss of virologic response and resistance.
How serious is the interaction between Enzalutamide and Fostemsavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if inducer exposure was recent.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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