Drug interactions
Buprenorphine + Lapatinib
Severity: Moderate
Buprenorphine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval and buprenorphine may add to this. Lapatinib also inhibits CYP3A4 weakly to moderately, which could modestly raise buprenorphine levels.
What this interaction means in plain words
Buprenorphine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition reducing buprenorphine clearance.
What to do
Obtain a baseline ECG, correct hypokalemia and hypomagnesemia, and repeat the ECG periodically. Monitor for increased sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Buprenorphine with Lapatinib?
MediHelp rates the interaction as moderate. Buprenorphine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval and buprenorphine may add to this. Lapatinib also inhibits CYP3A4 weakly to moderately, which could modestly raise buprenorphine levels.
How serious is the interaction between Buprenorphine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct hypokalemia and hypomagnesemia, and repeat the ECG periodically. Monitor for increased sedation.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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