Drug interactions
Buprenorphine + Methocarbamol
Severity: Moderate
Buprenorphine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol causes sedation and dizziness, which can add to the CNS depression produced by buprenorphine. Impaired alertness and, less commonly, respiratory depression may result.
What this interaction means in plain words
Buprenorphine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for excessive sedation and slowed breathing. Counsel the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Methocarbamol
Frequently asked questions
Can I take Buprenorphine with Methocarbamol?
MediHelp rates the interaction as moderate. Buprenorphine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol causes sedation and dizziness, which can add to the CNS depression produced by buprenorphine. Impaired alertness and, less commonly, respiratory depression may result.
How serious is the interaction between Buprenorphine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and slowed breathing. Counsel the patient to avoid driving and alcohol.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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