Drug interactions
Buprenorphine + Oliceridine
Severity: Major
Buprenorphine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine binds mu receptors tightly as a partial agonist and may blunt the analgesia of oliceridine. In opioid-dependent patients it may also precipitate withdrawal, and additive respiratory depression is possible.
What this interaction means in plain words
Buprenorphine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Partial agonist competition at mu-opioid receptors against a full agonist, with additive respiratory depression.
What to do
Avoid concurrent use where possible, and monitor pain control, withdrawal signs and respiratory status if oliceridine is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Buprenorphine with Oliceridine?
MediHelp rates the interaction as major. Buprenorphine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine binds mu receptors tightly as a partial agonist and may blunt the analgesia of oliceridine. In opioid-dependent patients it may also precipitate withdrawal, and additive respiratory depression is possible.
How serious is the interaction between Buprenorphine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, and monitor pain control, withdrawal signs and respiratory status if oliceridine is needed.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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