Drug interactions
Buprenorphine buccal + Chlorpheniramine
Severity: Moderate
Buprenorphine buccal and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating antihistamine increases drowsiness and may cause respiratory depression.
What this interaction means in plain words
Buprenorphine buccal and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation and breathing, and limit the sedative dose. Use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Buprenorphine buccal with Chlorpheniramine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a sedating antihistamine increases drowsiness and may cause respiratory depression.
How serious is the interaction between Buprenorphine buccal and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and breathing, and limit the sedative dose. Use a non-sedating antihistamine where possible.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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