Drug interactions
Buprenorphine buccal + Cyclizine
Severity: Moderate
Buprenorphine buccal and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating antihistamine can increase drowsiness and respiratory depression. Risk is greatest in opioid-naive, elderly or respiratory-compromised patients.
What this interaction means in plain words
Buprenorphine buccal and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation and respiratory rate, and use the lowest effective doses of each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Buprenorphine buccal with Cyclizine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a sedating antihistamine can increase drowsiness and respiratory depression. Risk is greatest in opioid-naive, elderly or respiratory-compromised patients.
How serious is the interaction between Buprenorphine buccal and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and use the lowest effective doses of each drug.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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