Drug interactions
Buprenorphine buccal + Desipramine
Severity: Major
Buprenorphine buccal and Desipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, and buprenorphine adds CNS depression to the sedating effects of a tricyclic antidepressant. Together they may raise the risk of torsades de pointes and excessive sedation.
What this interaction means in plain words
Buprenorphine buccal and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and additive CNS depressant effects.
What to do
Prefer an alternative where possible. If both are needed, obtain a baseline ECG, correct electrolytes, use the lowest effective doses, and monitor QTc and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Desipramine?
MediHelp rates the interaction as major. Buprenorphine buccal and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, and buprenorphine adds CNS depression to the sedating effects of a tricyclic antidepressant. Together they may raise the risk of torsades de pointes and excessive sedation.
How serious is the interaction between Buprenorphine buccal and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative where possible. If both are needed, obtain a baseline ECG, correct electrolytes, use the lowest effective doses, and monitor QTc and sedation.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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