Drug interactions
Buprenorphine buccal + Eltrombopag
Severity: Minor
Buprenorphine buccal and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine and its metabolite norbuprenorphine undergo glucuronidation by UGT1A1 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so exposure could rise, though no clinical effect has been established.
What this interaction means in plain words
Buprenorphine buccal and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
In vitro UGT inhibition by eltrombopag may reduce buprenorphine glucuronidation.
What to do
Monitor for sedation and respiratory depression after starting eltrombopag. Lower the buprenorphine dose if opioid excess appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Buprenorphine buccal with Eltrombopag?
MediHelp rates the interaction as minor. Buprenorphine buccal and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buprenorphine and its metabolite norbuprenorphine undergo glucuronidation by UGT1A1 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so exposure could rise, though no clinical effect has been established.
How serious is the interaction between Buprenorphine buccal and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression after starting eltrombopag. Lower the buprenorphine dose if opioid excess appears.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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