Drug interactions
Buprenorphine buccal + Levofloxacin
Severity: Moderate
Buprenorphine buccal and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buccal buprenorphine can prolong the QT interval, and levofloxacin adds to this effect. The risk of arrhythmia is higher in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Buprenorphine buccal and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider a non-QT-prolonging antibiotic. If both are used, obtain a baseline ECG and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Buprenorphine buccal with Levofloxacin?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buccal buprenorphine can prolong the QT interval, and levofloxacin adds to this effect. The risk of arrhythmia is higher in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Buprenorphine buccal and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic. If both are used, obtain a baseline ECG and monitor electrolytes.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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