Drug interactions
Buprenorphine buccal + Maprotiline
Severity: Major
Buprenorphine buccal and Maprotiline: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can increase sedation and respiratory depression, and both drugs have been linked to QT prolongation. The overall risk is greater at higher doses or with other depressants.
What this interaction means in plain words
Buprenorphine buccal and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression plus additive QT prolongation.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and ECG when risk factors exist. Counsel on avoiding alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Maprotiline?
MediHelp rates the interaction as major. Buprenorphine buccal and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined use can increase sedation and respiratory depression, and both drugs have been linked to QT prolongation. The overall risk is greater at higher doses or with other depressants.
How serious is the interaction between Buprenorphine buccal and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and ECG when risk factors exist. Counsel on avoiding alcohol and other sedatives.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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