Drug interactions
Buprenorphine buccal + Mifepristone
Severity: Moderate
Buprenorphine buccal and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so use together adds to the risk of torsades de pointes. Mifepristone may also raise buprenorphine levels via CYP3A4 inhibition.
What this interaction means in plain words
Buprenorphine buccal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation, plus possible CYP3A4 inhibition raising buprenorphine exposure.
What to do
Obtain an ECG at baseline and during therapy in patients with cardiac risk factors, and correct electrolyte abnormalities. Monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Mifepristone?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so use together adds to the risk of torsades de pointes. Mifepristone may also raise buprenorphine levels via CYP3A4 inhibition.
How serious is the interaction between Buprenorphine buccal and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during therapy in patients with cardiac risk factors, and correct electrolyte abnormalities. Monitor for oversedation and respiratory depression.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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