Drug interactions
Buprenorphine buccal + Sertraline
Severity: Moderate
Buprenorphine buccal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, particularly at higher doses, and sertraline may add a small effect. Buprenorphine with serotonergic drugs has also been associated with serotonin syndrome, and combined use may add sedation.
What this interaction means in plain words
Buprenorphine buccal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and additive serotonergic activity.
What to do
Monitor for serotonin toxicity and excessive sedation, and obtain an ECG if other QT risk factors exist. Use the lowest effective buprenorphine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Sertraline?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval, particularly at higher doses, and sertraline may add a small effect. Buprenorphine with serotonergic drugs has also been associated with serotonin syndrome, and combined use may add sedation.
How serious is the interaction between Buprenorphine buccal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and excessive sedation, and obtain an ECG if other QT risk factors exist. Use the lowest effective buprenorphine dose.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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