Drug interactions
Buprenorphine long-acting + Buspirone
Severity: Moderate
Buprenorphine long-acting and Buspirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone causes mild sedation and dizziness, which may add to the CNS and respiratory depression of buprenorphine. The effect is smaller than with benzodiazepines but still relevant given the long duration of the depot injection.
What this interaction means in plain words
Buprenorphine long-acting and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between opioid agonism and buspirone's sedative effects.
What to do
Monitor for sedation, dizziness and respiratory depression, particularly when starting or adjusting buspirone. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine long-acting and Buspirone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Buspirone?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone causes mild sedation and dizziness, which may add to the CNS and respiratory depression of buprenorphine. The effect is smaller than with benzodiazepines but still relevant given the long duration of the depot injection.
How serious is the interaction between Buprenorphine long-acting and Buspirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and respiratory depression, particularly when starting or adjusting buspirone. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
