Drug interactions
Buprenorphine long-acting + Captopril-hydrochlorothiazide
Severity: Minor
Buprenorphine long-acting and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and may reduce the diuretic effect of hydrochlorothiazide. Opioids may also add to orthostatic hypotension with antihypertensives. The clinical effect is usually modest.
What this interaction means in plain words
Buprenorphine long-acting and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release opposing diuresis, with additive hypotension from opioid-mediated vasodilation.
What to do
Monitor blood pressure, fluid status and edema, and adjust the diuretic if the effect weakens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Buprenorphine long-acting with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and may reduce the diuretic effect of hydrochlorothiazide. Opioids may also add to orthostatic hypotension with antihypertensives. The clinical effect is usually modest.
How serious is the interaction between Buprenorphine long-acting and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and edema, and adjust the diuretic if the effect weakens.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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