Drug interactions
Buprenorphine long-acting + Cariprazine
Severity: Moderate
Buprenorphine long-acting and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine and long-acting injectable buprenorphine both depress the CNS, which may increase drowsiness and psychomotor impairment. Because the injection provides prolonged exposure, any additive sedation may persist for an extended time.
What this interaction means in plain words
Buprenorphine long-acting and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from opioid receptor agonism and antipsychotic sedative effects.
What to do
Monitor for sedation and respiratory depression, especially early after injection and with dose changes of cariprazine. Avoid other CNS depressants and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Buprenorphine long-acting with Cariprazine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine and long-acting injectable buprenorphine both depress the CNS, which may increase drowsiness and psychomotor impairment. Because the injection provides prolonged exposure, any additive sedation may persist for an extended time.
How serious is the interaction between Buprenorphine long-acting and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially early after injection and with dose changes of cariprazine. Avoid other CNS depressants and alcohol.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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