Drug interactions
Buprenorphine long-acting + Cisatracurium
Severity: Moderate
Buprenorphine long-acting and Cisatracurium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as buprenorphine add to the sedative and respiratory depressant effects of other agents used in anesthesia and critical care. Cisatracurium itself is not sedating but paralysis with any opioid effect can mask or worsen respiratory compromise, particularly if ventilation is not secured.
What this interaction means in plain words
Buprenorphine long-acting and Cisatracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated central respiratory depression combined with peripheral neuromuscular paralysis from cisatracurium.
What to do
Use cisatracurium only with controlled ventilation and continuous monitoring. Ensure full reversal and recovery of respiratory function before ventilatory support is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Buprenorphine long-acting with Cisatracurium?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Cisatracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as buprenorphine add to the sedative and respiratory depressant effects of other agents used in anesthesia and critical care. Cisatracurium itself is not sedating but paralysis with any opioid effect can mask or worsen respiratory compromise, particularly if ventilation is not secured.
How serious is the interaction between Buprenorphine long-acting and Cisatracurium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use cisatracurium only with controlled ventilation and continuous monitoring. Ensure full reversal and recovery of respiratory function before ventilatory support is withdrawn.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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