Drug interactions
Buprenorphine long-acting + Glycopyrronium
Severity: Moderate
Buprenorphine long-acting and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as buprenorphine slow gut and bladder motility, and anticholinergics like glycopyrronium add to this. The combination increases the risk of severe constipation, paralytic ileus and urinary retention.
What this interaction means in plain words
Buprenorphine long-acting and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive reduction of gastrointestinal and urinary tract motility through opioid effects and muscarinic blockade.
What to do
Monitor bowel function and urinary symptoms, and use a prophylactic laxative; reduce or stop glycopyrronium if ileus or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Frequently asked questions
Can I take Buprenorphine long-acting with Glycopyrronium?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as buprenorphine slow gut and bladder motility, and anticholinergics like glycopyrronium add to this. The combination increases the risk of severe constipation, paralytic ileus and urinary retention.
How serious is the interaction between Buprenorphine long-acting and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms, and use a prophylactic laxative; reduce or stop glycopyrronium if ileus or retention develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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