Drug interactions
Buprenorphine long-acting + Lapatinib
Severity: Moderate
Buprenorphine long-acting and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may add to the risk of arrhythmia. Long-acting injections keep buprenorphine exposure going for weeks, so the effect cannot be quickly reversed.
What this interaction means in plain words
Buprenorphine long-acting and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check an ECG and electrolytes before starting and periodically during therapy. Correct potassium and magnesium, and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Buprenorphine long-acting with Lapatinib?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may add to the risk of arrhythmia. Long-acting injections keep buprenorphine exposure going for weeks, so the effect cannot be quickly reversed.
How serious is the interaction between Buprenorphine long-acting and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes before starting and periodically during therapy. Correct potassium and magnesium, and review other QT-prolonging drugs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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