Drug interactions
Buprenorphine long-acting + Levofloxacin
Severity: Moderate
Buprenorphine long-acting and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting buprenorphine injection has some QT-prolonging potential, and levofloxacin adds to it. Risk is greater with other arrhythmia risk factors.
What this interaction means in plain words
Buprenorphine long-acting and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider an alternative antibiotic in patients with QT risk factors. If both are used, check ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Buprenorphine long-acting with Levofloxacin?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting buprenorphine injection has some QT-prolonging potential, and levofloxacin adds to it. Risk is greater with other arrhythmia risk factors.
How serious is the interaction between Buprenorphine long-acting and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors. If both are used, check ECG and electrolytes.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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