Drug interactions
Buprenorphine long-acting + Maprotiline
Severity: Major
Buprenorphine long-acting and Maprotiline: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use with a sedating antidepressant increases the risk of profound sedation and respiratory depression. Long-acting injection prolongs exposure, so the effect cannot be quickly reversed.
What this interaction means in plain words
Buprenorphine long-acting and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Use only when alternatives are inadequate, with the lowest effective doses, and monitor for sedation and respiratory depression. Avoid adding other sedatives or alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Maprotiline?
MediHelp rates the interaction as major. Buprenorphine long-acting and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use with a sedating antidepressant increases the risk of profound sedation and respiratory depression. Long-acting injection prolongs exposure, so the effect cannot be quickly reversed.
How serious is the interaction between Buprenorphine long-acting and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when alternatives are inadequate, with the lowest effective doses, and monitor for sedation and respiratory depression. Avoid adding other sedatives or alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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