Drug interactions
Buprenorphine long-acting + Ramelteon
Severity: Moderate
Buprenorphine long-acting and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine provides prolonged opioid exposure, and adding a sedative-hypnotic such as ramelteon may increase sedation. Respiratory depression is possible, and the injected drug cannot be quickly withdrawn.
What this interaction means in plain words
Buprenorphine long-acting and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Assess the need for ramelteon and use the lowest effective dose, monitoring for sedation and respiratory depression. Counsel on avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Buprenorphine long-acting with Ramelteon?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine provides prolonged opioid exposure, and adding a sedative-hypnotic such as ramelteon may increase sedation. Respiratory depression is possible, and the injected drug cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine long-acting and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the need for ramelteon and use the lowest effective dose, monitoring for sedation and respiratory depression. Counsel on avoiding alcohol and other sedatives.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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