Drug interactions
Buprenorphine long-acting + Secobarbital
Severity: Major
Buprenorphine long-acting and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital induces CYP3A4 and may reduce buprenorphine levels, risking withdrawal or poor opioid-use-disorder control. Barbiturates also add to opioid-related sedation and respiratory depression.
What this interaction means in plain words
Buprenorphine long-acting and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction increases buprenorphine clearance, plus additive CNS and respiratory depression.
What to do
Monitor for withdrawal symptoms, adequacy of buprenorphine effect, and sedation. If the inducer is unavoidable, return to a dose-adjustable buprenorphine formulation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Secobarbital?
MediHelp rates the interaction as major. Buprenorphine long-acting and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital induces CYP3A4 and may reduce buprenorphine levels, risking withdrawal or poor opioid-use-disorder control. Barbiturates also add to opioid-related sedation and respiratory depression.
How serious is the interaction between Buprenorphine long-acting and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms, adequacy of buprenorphine effect, and sedation. If the inducer is unavoidable, return to a dose-adjustable buprenorphine formulation.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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