Drug interactions
Buprenorphine long-acting + Vardenafil
Severity: Moderate
Buprenorphine long-acting and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may raise the risk of torsades de pointes. The effect of vardenafil on QT is modest, and the risk is greatest in patients with other risk factors.
What this interaction means in plain words
Buprenorphine long-acting and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium abnormalities. Consider an alternative to vardenafil if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Vardenafil?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may raise the risk of torsades de pointes. The effect of vardenafil on QT is modest, and the risk is greatest in patients with other risk factors.
How serious is the interaction between Buprenorphine long-acting and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium abnormalities. Consider an alternative to vardenafil if the QTc becomes prolonged.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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