Drug interactions
Buprenorphine subdermal implant + Lapatinib
Severity: Moderate
Buprenorphine subdermal implant and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them may add to the risk of ventricular arrhythmia. The implant gives low, steady buprenorphine levels, so the added effect is probably small.
What this interaction means in plain words
Buprenorphine subdermal implant and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes, and repeat the ECG if other QT-prolonging drugs are added or symptoms occur. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Lapatinib?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them may add to the risk of ventricular arrhythmia. The implant gives low, steady buprenorphine levels, so the added effect is probably small.
How serious is the interaction between Buprenorphine subdermal implant and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and repeat the ECG if other QT-prolonging drugs are added or symptoms occur. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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