Drug interactions
Buprenorphine subdermal implant + Mifepristone
Severity: Moderate
Buprenorphine subdermal implant and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have QTc-prolonging potential, so combined use may add to arrhythmia risk. Buprenorphine implant has a low QT effect at its steady exposure.
What this interaction means in plain words
Buprenorphine subdermal implant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization; possible CYP3A4 inhibition may raise buprenorphine levels.
What to do
Check an ECG when other risk factors for QT prolongation are present and keep potassium and magnesium normal. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Mifepristone?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have QTc-prolonging potential, so combined use may add to arrhythmia risk. Buprenorphine implant has a low QT effect at its steady exposure.
How serious is the interaction between Buprenorphine subdermal implant and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG when other risk factors for QT prolongation are present and keep potassium and magnesium normal. Monitor for sedation and respiratory depression.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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