Drug interactions
Buprenorphine subdermal implant + Oxymorphone
Severity: Major
Buprenorphine subdermal implant and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine from an implant occupies mu receptors continuously and can blunt the effect of a full agonist like oxymorphone. It may also precipitate withdrawal in dependent patients, and additive sedation is possible.
What this interaction means in plain words
Buprenorphine subdermal implant and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Partial agonist receptor competition with a full agonist plus additive CNS depression.
What to do
Avoid combining unless essential; monitor for reduced analgesia, withdrawal and respiratory depression. Seek specialist input for pain management in implant patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Oxymorphone?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine from an implant occupies mu receptors continuously and can blunt the effect of a full agonist like oxymorphone. It may also precipitate withdrawal in dependent patients, and additive sedation is possible.
How serious is the interaction between Buprenorphine subdermal implant and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless essential; monitor for reduced analgesia, withdrawal and respiratory depression. Seek specialist input for pain management in implant patients.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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