Drug interactions
Buprenorphine subdermal implant + Primaquine
Severity: Moderate
Buprenorphine subdermal implant and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, though effects at implant exposures are modest, and primaquine may add to this effect. Risk is greatest in patients with other QT risk factors.
What this interaction means in plain words
Buprenorphine subdermal implant and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG in patients with cardiac risk factors during primaquine therapy and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Primaquine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval, though effects at implant exposures are modest, and primaquine may add to this effect. Risk is greatest in patients with other QT risk factors.
How serious is the interaction between Buprenorphine subdermal implant and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors during primaquine therapy and correct electrolyte abnormalities.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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