Drug interactions
Anagrelide + Primaquine
Severity: Major
Anagrelide and Primaquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have QT-prolonging potential, and anagrelide can also cause tachycardia and palpitations. Combined use raises the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Anagrelide and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination if possible. If necessary, check a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
- Bedaquiline + Primaquine Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Primaquine?
MediHelp rates the interaction as major. Anagrelide and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have QT-prolonging potential, and anagrelide can also cause tachycardia and palpitations. Combined use raises the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Anagrelide and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, check a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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