Drug interactions
Buprenorphine transdermal + Levofloxacin
Severity: Moderate
Buprenorphine transdermal and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Transdermal buprenorphine carries a labeled QT warning, and risk is greater with other contributing factors.
What this interaction means in plain words
Buprenorphine transdermal and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain an ECG and check electrolytes if the patient has other QT risk factors, and correct any abnormalities. Consider an alternative antibiotic in patients with known long QT or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Buprenorphine transdermal with Levofloxacin?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Transdermal buprenorphine carries a labeled QT warning, and risk is greater with other contributing factors.
How serious is the interaction between Buprenorphine transdermal and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes if the patient has other QT risk factors, and correct any abnormalities. Consider an alternative antibiotic in patients with known long QT or arrhythmia.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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