Drug interactions
Buprenorphine transdermal + Methocarbamol
Severity: Major
Buprenorphine transdermal and Methocarbamol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol causes sedation and dizziness. Combined with transdermal buprenorphine, it can cause additive sedation, respiratory depression and psychomotor impairment, and buprenorphine remains active for a long time after patch removal.
What this interaction means in plain words
Buprenorphine transdermal and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism between an opioid and a sedating muscle relaxant.
What to do
Reserve the combination for patients without adequate alternatives, using minimal doses and duration. Monitor for sedation and respiratory depression, particularly after dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methocarbamol
Frequently asked questions
Can I take Buprenorphine transdermal with Methocarbamol?
MediHelp rates the interaction as major. Buprenorphine transdermal and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methocarbamol causes sedation and dizziness. Combined with transdermal buprenorphine, it can cause additive sedation, respiratory depression and psychomotor impairment, and buprenorphine remains active for a long time after patch removal.
How serious is the interaction between Buprenorphine transdermal and Methocarbamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, using minimal doses and duration. Monitor for sedation and respiratory depression, particularly after dose changes.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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