Drug interactions
Bupropion + Selegiline transdermal
Severity: Contraindicated
Bupropion and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
What this interaction means in plain words
Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Bupropion inhibits dopamine and norepinephrine reuptake while MAO inhibition reduces their breakdown, producing additive catecholaminergic effects.
What to do
Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Thioridazine Contraindicated
Frequently asked questions
Can I take Bupropion with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
How serious is the interaction between Bupropion and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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