Drug interactions
Buspirone + Butabarbital
Severity: Moderate
Buspirone and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes and may lower buspirone concentrations, reducing its anxiolytic effect. Both also cause CNS depression, so sedation may be additive.
What this interaction means in plain words
Buspirone and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by barbiturate increases buspirone metabolism; additive CNS depression.
What to do
Monitor anxiolytic response and increase buspirone dose if needed. Watch for sedation and re-evaluate the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Butabarbital?
MediHelp rates the interaction as moderate. Buspirone and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital induces hepatic enzymes and may lower buspirone concentrations, reducing its anxiolytic effect. Both also cause CNS depression, so sedation may be additive.
How serious is the interaction between Buspirone and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anxiolytic response and increase buspirone dose if needed. Watch for sedation and re-evaluate the dose if the barbiturate is stopped.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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