Drug interactions
Buspirone + Butalbital
Severity: Moderate
Buspirone and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital may induce CYP3A4 and reduce buspirone exposure, potentially weakening its effect. Both agents can cause drowsiness.
What this interaction means in plain words
Buspirone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increasing buspirone clearance; additive CNS depression.
What to do
Monitor for loss of anxiolytic efficacy and for sedation. Adjust buspirone dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Butalbital?
MediHelp rates the interaction as moderate. Buspirone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital may induce CYP3A4 and reduce buspirone exposure, potentially weakening its effect. Both agents can cause drowsiness.
How serious is the interaction between Buspirone and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of anxiolytic efficacy and for sedation. Adjust buspirone dose based on response.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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