Drug interactions
Buspirone + Cenobamate
Severity: Moderate
Buspirone and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower buspirone concentrations, reducing efficacy. Both drugs also cause somnolence and dizziness.
What this interaction means in plain words
Buspirone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Cenobamate belongs to Central Nervous System.
Why it happens
CYP3A4 induction by cenobamate increases buspirone metabolism, plus additive CNS effects.
What to do
Monitor response and increase buspirone dose if needed. Monitor for sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Buspirone with Cenobamate?
MediHelp rates the interaction as moderate. Buspirone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower buspirone concentrations, reducing efficacy. Both drugs also cause somnolence and dizziness.
How serious is the interaction between Buspirone and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and increase buspirone dose if needed. Monitor for sedation and dizziness.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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