Drug interactions
Buspirone + Dexfenfluramine
Severity: Moderate
Buspirone and Dexfenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and inhibits its reuptake, while buspirone is a 5-HT1A agonist. The combination may increase the risk of serotonin syndrome. Dexfenfluramine is withdrawn in most markets.
What this interaction means in plain words
Buspirone and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic stimulation from serotonin release and receptor agonism.
What to do
Avoid the combination; if encountered, monitor for signs of serotonin syndrome such as agitation, tremor, hyperreflexia and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buspirone and Dexfenfluramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Dexfenfluramine?
MediHelp rates the interaction as moderate. Buspirone and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine releases serotonin and inhibits its reuptake, while buspirone is a 5-HT1A agonist. The combination may increase the risk of serotonin syndrome. Dexfenfluramine is withdrawn in most markets.
How serious is the interaction between Buspirone and Dexfenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if encountered, monitor for signs of serotonin syndrome such as agitation, tremor, hyperreflexia and hyperthermia.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
