Drug interactions
Buspirone + Dextroamphetamine transdermal
Severity: Moderate
Buspirone and Dextroamphetamine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase release of serotonin and other monoamines and are labeled with a serotonin syndrome warning with serotonergic agents. Combined with buspirone, they may cause agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Buspirone and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from amphetamine-induced monoamine release and buspirone 5-HT1A agonism.
What to do
Start with low doses and monitor for serotonin syndrome, especially at initiation or dose increases. Discontinue the amphetamine and serotonergic agent if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Dextroamphetamine transdermal?
MediHelp rates the interaction as moderate. Buspirone and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase release of serotonin and other monoamines and are labeled with a serotonin syndrome warning with serotonergic agents. Combined with buspirone, they may cause agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Buspirone and Dextroamphetamine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for serotonin syndrome, especially at initiation or dose increases. Discontinue the amphetamine and serotonergic agent if it occurs.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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