Drug interactions
Buspirone + Dextroamphetamine
Severity: Moderate
Buspirone and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine increases release of monoamines including serotonin, and combined with buspirone this may raise the risk of serotonin toxicity. Amphetamines can also raise blood pressure and cause agitation, which may confound recognition.
What this interaction means in plain words
Buspirone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from amphetamine-induced monoamine release and buspirone 5-HT1A agonism.
What to do
Monitor for agitation, tremor, tachycardia and hyperthermia, especially when doses are started or raised. Stop the agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buspirone and Dextroamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Buspirone with Dextroamphetamine?
MediHelp rates the interaction as moderate. Buspirone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine increases release of monoamines including serotonin, and combined with buspirone this may raise the risk of serotonin toxicity. Amphetamines can also raise blood pressure and cause agitation, which may confound recognition.
How serious is the interaction between Buspirone and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, tachycardia and hyperthermia, especially when doses are started or raised. Stop the agents if serotonin syndrome is suspected.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
