Drug interactions
Buspirone + Esketamine intranasal
Severity: Moderate
Buspirone and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and dizziness, and buspirone can cause drowsiness. Together they may increase sedation and impair alertness after dosing.
What this interaction means in plain words
Buspirone and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and sedative effects.
What to do
Observe patients during the post-dose monitoring period for excessive sedation. Advise patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Esketamine intranasal?
MediHelp rates the interaction as moderate. Buspirone and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and dizziness, and buspirone can cause drowsiness. Together they may increase sedation and impair alertness after dosing.
How serious is the interaction between Buspirone and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe patients during the post-dose monitoring period for excessive sedation. Advise patients not to drive until the next day after a restful sleep.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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