Drug interactions
Buspirone + Esketamine
Severity: Minor
Buspirone and Esketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone can cause dizziness and drowsiness, and esketamine causes sedation, dissociation and blood pressure elevation. Combined effects on alertness may be modestly additive.
What this interaction means in plain words
Buspirone and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Mild additive CNS effects.
What to do
Monitor sedation and blood pressure during esketamine sessions; no dose change is typically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Esketamine?
MediHelp rates the interaction as minor. Buspirone and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buspirone can cause dizziness and drowsiness, and esketamine causes sedation, dissociation and blood pressure elevation. Combined effects on alertness may be modestly additive.
How serious is the interaction between Buspirone and Esketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during esketamine sessions; no dose change is typically needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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